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KMID : 0357520170400020275
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Journal of Radiological Science and Technology
2017 Volume.40 No. 2 p.275 ~ p.280
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Effect of Glucose Level on Brain FDG-PET Images
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Kim In-Yeong
Lee Yong-Ki
Ahn Sung-Min
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Abstract
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In addition to tumors, normal tissues, such as the brain and myocardium can intake 18F-FDG, and the amount of 18F-FDG intake by normal tissues can be altered by the surrounding environment. Therefore, a process is necessary during which the contrasts of the tumor and normal tissues can be enhanced. Thus, this study examines the effects of glucose levels on FDG PET images of brain tissues, which features high glucose activity at all times, in small animals. Micro PET scan was performed on fourteen mice after injecting 18F-FDG. The images were compared in relation to fasting. The findings showed that the mean S UV v alue w as 0 .84 higher i n fasted m ice than i n non-fasted m ice. D uring observation, the i mages from non-fasted mice showed high accumulation in organs other than the brain with increased surrounding noise. In addition, compared to the non-fasted mice, the fasted mice showed higher early intake and curve increase.
The findings of this study suggest that fasting is important in assessing brain functions in brain PET using 18F-FDG. Additional studies to investigate whether caffeine levels and other preprocessing items have an impact on the acquired images would contribute to reducing radiation exposure in patients.
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KEYWORD
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Glucose , Standard uptake value(SUV) , PET , FDG
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